Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells.

@article{Coll2010ActivationOP,
  title={Activation of peroxisome proliferator-activated receptor-\{delta\} by GW501516 prevents fatty acid-induced nuclear factor-\{kappa\}B activation and insulin resistance in skeletal muscle cells.},
  author={Teresa Coll and David {\'A}lvarez-Guardia and Emma Barroso and Anna Maria G{\'o}mez-Foix and Xavier Palomer and Juan Carlos Laguna and Manuel V{\'a}zquez-Carrera},
  journal={Endocrinology},
  year={2010},
  volume={151 4},
  pages={1560-9}
}
Elevated plasma free fatty acids cause insulin resistance in skeletal muscle through the activation of a chronic inflammatory process. This process involves nuclear factor (NF)-kappaB activation as a result of diacylglycerol (DAG) accumulation and subsequent protein kinase Ctheta (PKCtheta) phosphorylation. At present, it is unknown whether peroxisome proliferator-activated receptor-delta (PPARdelta) activation prevents fatty acid-induced inflammation and insulin resistance in skeletal muscle… CONTINUE READING
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