Activation of peripheral opioid receptors has no effect on heart rate variability

@article{Ellidokuz2008ActivationOP,
  title={Activation of peripheral opioid receptors has no effect on heart rate variability},
  author={PhD Dr. Ender Ellidokuz and Dayimi Kaya and İhsan Uslan and Ataç Çelik and Ali Metin Esen and İrfan Barutça},
  journal={Clinical Autonomic Research},
  year={2008},
  volume={18},
  pages={145-149}
}
Opioid receptors involved in regulating the motility of the gastrointestinal tract have been localized in both contractile and neuronal tissues. Trimebutine, a peripheral opioid receptor agonist, modulates gastrointestinal motor activity in both directions and also may act on cardiac tissue. This study investigated the effects of trimebutine in clinical doses on cardiac autonomic functions with heart rate variability. The effect of trimebutine on cardiac autonomic outflows was evaluated in 11… CONTINUE READING