Corpus ID: 3001386

Activation of peripheral kappa opioid receptors inhibits capsaicin-induced thermal nociception in rhesus monkeys.

@article{Ko1999ActivationOP,
  title={Activation of peripheral kappa opioid receptors inhibits capsaicin-induced thermal nociception in rhesus monkeys.},
  author={M. Ko and E. Butelman and J. Woods},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={289 1},
  pages={
          378-85
        }
}
  • M. Ko, E. Butelman, J. Woods
  • Published 1999
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 8-Methyl-N-vanillyl-6-nonenamide (capsaicin) was locally applied in the tail of rhesus monkeys to evoke a nociceptive response, thermal allodynia, which was manifested as reduced tail-withdrawal latencies in normally innocuous 46 degrees C water. Coadministration of three kappa opioid ligands, U50,488 (3.2-100 microgram), bremazocine (0.1-3.2 microgram), and dynorphin A(1-13) (3.2-100 microgram), with capsaicin in the tail dose-dependently inhibited capsaicin-induced allodynia. This local… CONTINUE READING
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