Activation of peripheral kappa/delta opioid receptors mediates 15-deoxy-(Delta12,14)-prostaglandin J2 induced-antinociception in rat temporomandibular joint.

@article{PenaDosSantos2009ActivationOP,
  title={Activation of peripheral kappa/delta opioid receptors mediates 15-deoxy-(Delta12,14)-prostaglandin J2 induced-antinociception in rat temporomandibular joint.},
  author={Diego R Pena-Dos-Santos and Fernando P Severino and San{\'i}via Aparecida de Lima Pereira and Denise Bertulucci Rocha Rodrigues and Fernando Q Cunha and Silvio M Vieira and Marcelo Henrique Napimoga and Juliana Trindade Clemente-Napimoga},
  journal={Neuroscience},
  year={2009},
  volume={163 4},
  pages={1211-9}
}
This study assessed the effect of the agonist 15d-PGJ(2) administered into the rat temporomandibular joint (TMJ) on nociceptive behavioral and the anti-inflammatory potential of this prostaglandin on TMJ. It was observed that 15-deoxy-(Delta12,14)-prostaglandin J(2) (15d-PGJ(2)) significantly reduced formalin-induced nociceptive behavior in a dose dependent manner, however injection of 15d-PGJ(2) into the contralateral TMJ failed to reduce such effects. This antinociceptive effect is dependent… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…