Activation of peripheral blood T cells by interaction and migration through endothelium: role of lymphocyte function antigen-1/intercellular adhesion molecule-1 and interleukin-15.

@article{Sancho1999ActivationOP,
  title={Activation of peripheral blood T cells by interaction and migration through endothelium: role of lymphocyte function antigen-1/intercellular adhesion molecule-1 and interleukin-15.},
  author={David de Sancho and Mar{\'i}a Y{\'a}{\~n}ez-M{\'o} and Reyes Tejedor and Francisco S{\'a}nchez-Madrid},
  journal={Blood},
  year={1999},
  volume={93 3},
  pages={886-96}
}
Cell adhesion molecules have a key role in the migration of T cells to inflammatory foci. However, the effect of the endothelial-lymphocyte interaction on the activation of the latter cells remains unresolved. We have studied the effect of resting and stimulated endothelial cells (ECs) on the activation of peripheral blood T cells (PBTLs), as assessed by the expression of CD69 and CD25 activation antigens. The incubation of PBTLs with tumor necrosis factor-alpha-activated EC monolayers, either… CONTINUE READING
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