Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis.

@article{Haber1999ActivationOP,
  title={Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis.},
  author={Paul S Haber and Gregory Keogh and Minoti Vivek Apte and Corey S. Moran and Nick Meader Kristel King Alexis Llewellyn Gill Norman J Stewart and Darrell H G Crawford and Romano Cesare Pirola and Geoffrey W Mccaughan and Grant A Ramm and Jeremy Somers Wilson},
  journal={The American journal of pathology},
  year={1999},
  volume={155 4},
  pages={1087-95}
}
The mechanisms of pancreatic fibrosis are poorly understood. In the liver, stellate cells play an important role in fibrogenesis. Similar cells have recently been isolated from the pancreas and are termed pancreatic stellate cells. The aim of this study was to determine whether pancreatic stellate cell activation occurs during experimental and human pancreatic fibrosis. Pancreatic fibrosis was induced in rats (n = 24) by infusion of trinitrobenzene sulfonic acid (TNBS) into the pancreatic duct… CONTINUE READING
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