Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts.

@article{Brenneisen2000ActivationOP,
  title={Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts.},
  author={Peter Brenneisen and Jutta Wenk and Meinhard Wlaschek and Thomas M. Krieg and Karin Scharffetter-Kochanek},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 6},
  pages={4336-44}
}
Ultraviolet B (UVB) irradiation has been shown to stimulate the expression of matrix-degrading metalloproteinases via generation of DNA damage and/or reactive oxygen species. Matrix-degrading metalloproteinases promote UVB-triggered detrimental long term effects like cancer formation and premature skin aging. Here, we were interested in identifying components of the signal transduction pathway that causally link UVB-mediated DNA damage and induction of matrix-degrading metalloproteinase (MMP)-1… CONTINUE READING

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Here , we were interested in identifying components of the signal transduction pathway that causally link UVB - mediated DNA damage and induction of matrix - degrading metalloproteinase ( MMP)-1/interstitial collagenase and MMP-3/stromelysin-1 in human dermal fibroblasts in vitro .
Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage - dependent signaling pathway responsible for the ultraviolet B - mediated increase in interstitial collagenase ( MMP-1 ) and stromelysin-1 ( MMP-3 ) protein levels in human dermal fibroblasts .
Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage - dependent signaling pathway responsible for the ultraviolet B - mediated increase in interstitial collagenase ( MMP-1 ) and stromelysin-1 ( MMP-3 ) protein levels in human dermal fibroblasts .
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