Activation of p53 protein by telomeric (TTAGGG)n repeats.

  title={Activation of p53 protein by telomeric (TTAGGG)n repeats.},
  author={Michael Milyavsky and Avishai Mimran and Shai Senderovich and Irit Zurer and Neta Erez and Igor Shats and Naomi Goldfinger and Ilana E Cohen and Varda Rotter},
  journal={Nucleic acids research},
  volume={29 24},
Genome instability is a primary factor leading to the activation of the p53 tumor suppressor protein. Telomeric repeat (TR) sequences are also responsible for genome integrity. By capping the termini of the chromosomes, TRs prevent them undergoing nucleolytic degradation, ligation or chromosome fusion. Interestingly, telomere shortening was suggested to activate p53, which in turn may cause primary cells to senesce. In order to elucidate the nature of a possible cross talk between the two, we… CONTINUE READING

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