Activation of p53 by sodium selenite switched human leukemia NB4 cells from autophagy to apoptosis.

Abstract

It was revealed by our previous research that sodium selenite repressed autophagy accompanied by the induction of apoptosis in human leukemia NB4 cells. The inhibition of autophagy exerted a facilitative effect on apoptosis. In the present study, we further explored the mechanisms underlying the switch from autophagy to apoptosis and elucidated p53 played a… (More)
DOI: 10.3727/096504014X14024160459087

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