Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest.

Abstract

Clam oocytes are arrested naturally at the G2/M border in meiosis and contain an inactive 42 kDa ERK/MAP kinase, p42MAPK. Following fertilization, p42MAPK is rapidly phosphorylated on tyrosine residues and concomitantly activated. Both tyrosine phosphorylation and activation of p42MAPK begin within 2-3 min of fertilization, peak at approximately 15 min… (More)

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Cite this paper

@article{Shibuya1992ActivationOP, title={Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest.}, author={Etsuko Shibuya and T G Boulton and Mary In-Ping Huang Cobb and Joan V. Ruderman}, journal={The EMBO journal}, year={1992}, volume={11 11}, pages={3963-75} }