Activation of p38 has opposing effects on the proliferation and migration of endothelial cells.

@article{McMullen2005ActivationOP,
  title={Activation of p38 has opposing effects on the proliferation and migration of endothelial cells.},
  author={Meghan E McMullen and Patrick W. Bryant and Christopher C. Glembotski and Peter A. Vincent and Kevin M Pumiglia},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 22},
  pages={20995-1003}
}
Pathological conditions such as hypertension and hyperglycemia as well as abrasions following balloon angioplasty all lead to endothelial dysfunction that impacts disease morbidity. These conditions are associated with the elaboration of a variety of cytokines and increases in p38 activity in endothelial cells. However, the relationship between enhanced p38… CONTINUE READING