Activation of p38 MAPK is involved in endothelin-1-stimulated COX-2 expression in cultured Feline esophageal smooth muscle cells.

@article{Song2006ActivationOP,
  title={Activation of p38 MAPK is involved in endothelin-1-stimulated COX-2 expression in cultured Feline esophageal smooth muscle cells.},
  author={Hyun Ju Song and Y. S. Min and Chang Yell Shin and Ji Hoon Jeong and Uy Dong Sohn},
  journal={Molecules and cells},
  year={2006},
  volume={22 1},
  pages={44-50}
}
We investigated the possible role of p38 MAPK and ETB receptors in ET-1 induction of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) in cultured feline esophageal smooth muscle cells (ESMC). Confluent layers of ESMC were stimulated with 10 nM ET-1 and expression of COX-1 and COX-2, involvement of receptors, and activation of p38 MAPK, were examined by… CONTINUE READING