Activation of p38 MAPK induced by a multi-cycle ischaemic preconditioning protocol is associated with attenuated p38 MAPK activity during sustained ischaemia and reperfusion.

@article{Marais2001ActivationOP,
  title={Activation of p38 MAPK induced by a multi-cycle ischaemic preconditioning protocol is associated with attenuated p38 MAPK activity during sustained ischaemia and reperfusion.},
  author={Erna Marais and Sonia Genade and Barbara Huisamen and J G Strijdom and J A Moolman and Amanda Lochner},
  journal={Journal of molecular and cellular cardiology},
  year={2001},
  volume={33 4},
  pages={769-78}
}
The role of p38 mitogen-activated protein kinase (MAPK) in ischaemic preconditioning remains controversial. Since most previous studies focussed on events only during sustained ischaemia, the aim of this study was to establish the activation pattern of p38 MAPK during a multicycle preconditioning protocol, sustained ischaemia as well as reperfusion and to correlate these events with functional recovery of the isolated perfused rat heart. Isolated perfused rat hearts were preconditioned by 3x5… CONTINUE READING

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