Activation of p38 MAP kinase pathway by erythropoietin and interleukin-3.

  title={Activation of p38 MAP kinase pathway by erythropoietin and interleukin-3.},
  author={Yuka Nagata and Takashi Moriguchi and Eisuke Nishida and Kazuo Todokoro},
  volume={90 3},
Activation of p38 MAP kinase (p38) as well as JNK/SAPK has been described as being induced by a variety of environmental stresses such as osmotic shock, ultraviolet radiation, and heat shock, or the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1 (IL-1). We found that the hematopoietic cytokines erythropoietin (Epo) and IL-3, which regulate growth and differentiation of erythroids and hematopoietic progenitors, respectively, also activate a p38 cascade. Immunoblot… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 40 extracted citations


Publications referenced by this paper.
Showing 1-10 of 42 references

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.

The EMBO journal • 1996
View 4 Excerpts
Highly Influenced

Involvement activated protein kinase cascade

B Stein, H Brady, +6 authors Y Kaziro
J Biol Chem • 1996

Signal nick R : Acid sphingomyelinase - deficient human lymphoblasts andtransduction by the high - affinity GM - CSF receptor : Two distinct mice are defective in rediation - induced apoptosis

R Beyaert, A Cuenda, WV Berghe, S Plaisance, JC Lee
Cell • 1996

Activation of the SAPK path - vation

CJ Marshall, CM Pombo, +5 authors JM Kyriakis
Cell • 1995

Similar Papers

Loading similar papers…