Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis.

@article{Cheng2010ActivationOP,
  title={Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis.},
  author={Xiaoyun Cheng and Weiya Xia and Jer-Yen Yang and Jennifer L Hsu and Chao-Kai chou and H Sun and Shannon L. Wyszomierski and Gordon B. Mills and William J. Muller and Dihua Yu and M -C Hung},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={403 1},
  pages={103-7}
}
While p21 is well known to inhibit cyclin-CDK activity in the nucleus and it has also been demonstrated to have oncogenic properties in different types of human cancers. In vitro studies showed that the oncogenic function of p21is closely related to its cytoplasmic localization. However, it is unclear whether cytoplasmic p21 contributes to tumorigenesis in vivo. To address this question, we generated transgenic mice expressing the Akt-phosphorylated form of p21 (p21T145D) in the mammary… CONTINUE READING

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