Activation of p 75 NTR by proBDNF facilitates hippocampal long-term depression

  title={Activation of p 75 NTR by proBDNF facilitates hippocampal long-term depression},
  author={Newton H. Woo and Henry K. Teng and C Siao and Cristina Chiaruttini and Petti T. Pang and Teresa A Milner and Barbara L. Hempstead and Bai Lu},
Proand mature brain-derived neurotrophic factor (BDNF) activate two distinct receptors: p75 neurotrophin receptor (p75NTR) and TrkB. Mature BDNF facilitates hippocampal synaptic potentiation through TrkB. Here we report that proBDNF, by activating p75NTR, facilitates hippocampal long-term depression (LTD). Electron microscopy showed that p75NTR localized in dendritic spines, in addition to afferent terminals, of CA1 neurons. Deletion of p75NTR in mice selectively impaired the NMDA receptor… CONTINUE READING


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Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression

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