Activation of oxoglutarate dehydrogenase in the kidney in response to acute acidosis.

@article{Lowry1980ActivationOO,
  title={Activation of oxoglutarate dehydrogenase in the kidney in response to acute acidosis.},
  author={Martin Lowry and Brian D. Ross},
  journal={The Biochemical journal},
  year={1980},
  volume={190 3},
  pages={
          771-80
        }
}
1. Activation by H+ and by Ca2+ of 2-oxoglutarate dehydrogenase extracted from mitochondria of normal or acidotic rat kidney is described. This effect, first shown for the enzyme from heart by McCormack & Denton [Biochem. J. (1979) 180, 533--544], is of a regulatory importance in kidney, in which organ, in contrast with heart, increased flux occurs during acute acidosis. 2. In renal-cortical tubules, 2-oxoglutarate concentration fell within 1 min of decreasing the pH and rose again 1--3 min… CONTINUE READING
BETA

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 21 CITATIONS

Similar Papers

Loading similar papers…