Activation of osteocalcin transcription involves interaction of protein kinase A- and protein kinase C-dependent pathways.

@article{Boguslawski2000ActivationOO,
  title={Activation of osteocalcin transcription involves interaction of protein kinase A- and protein kinase C-dependent pathways.},
  author={George Boguslawski and Laura V Hale and Xiao Ping Yu and Rebecca R. Miles and Jude E. Onyia and Rock Santerre and Srinivasan Chandrasekhar},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 2},
  pages={999-1006}
}
Osteocalcin is a major noncollagenous protein component of bone extracellular matrix, synthesized and secreted exclusively by osteoblastic cells in the late stage of maturation, and is considered indicator of osteoblast differentiation. Osteocalcin expression is modulated by parathyroid hormone (PTH) and a variety of other factors. The cAMP-dependent protein kinase pathway has been shown previously to have an essential role in PTH signaling and regulation of osteocalcin expression. To determine… CONTINUE READING

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