Activation of orphan receptors by the hormone relaxin.

  title={Activation of orphan receptors by the hormone relaxin.},
  author={Sheau Yu Teddy Hsu and Koji Nakabayashi and Shinya Nishi and Jin Kumagai and Masataka Kudo and O. David Sherwood and Aaron J Hsueh},
  volume={295 5555},
Relaxin is a hormone important for the growth and remodeling of reproductive and other tissues during pregnancy. Although binding sites for relaxin are widely distributed, the nature of its receptor has been elusive. Here, we demonstrate that two orphan heterotrimeric guanine nucleotide binding protein (G protein)-coupled receptors, LGR7 and LGR8, are capable of mediating the action of relaxin through an adenosine 3',5'-monophosphate (cAMP)-dependent pathway distinct from that of the… CONTINUE READING
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