Activation of olfactory-type cyclic nucleotide-gated channels is highly cooperative.

  title={Activation of olfactory-type cyclic nucleotide-gated channels is highly cooperative.},
  author={Vasilica Nache and Eckhard Schulz and Thomas M Zimmer and Jana Kusch and Christoph Biskup and Rolf Koopmann and Volker Hagen and Klaus Benndorf},
  journal={The Journal of physiology},
  volume={569 Pt 1},
Cyclic nucleotide-gated (CNG) ion channels play a key role in the sensory transduction of vision and olfaction. The channels are opened by the binding of cyclic nucleotides. Native olfactory CNG channels are heterotetramers of CNGA2, CNGA4, and CNGB1b subunits. Upon heterologous expression, only CNGA2 subunits can form functional homotetrameric channels. It is presently not known how the binding of the ligands to the four subunits is translated to channel opening. We studied activation of… CONTINUE READING


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