Activation of olefins via asymmetric Brønsted acid catalysis

@article{Tsuji2018ActivationOO,
  title={Activation of olefins via asymmetric Br{\o}nsted acid catalysis},
  author={Nobuya Tsuji and Jennifer L Kennemur and Thomas Buyck and Sunggi Lee and S{\'e}bastien Pr{\'e}vost and Philip S. J. Kaib and Dmytro Bykov and Christophe Far{\'e}s and Benjamin List},
  journal={Science},
  year={2018},
  volume={359},
  pages={1501 - 1505}
}
Attacking olefins with chiral acids A little acid can accelerate a wide range of chemical reactions. The advent of chiral phosphoric acid derivatives has been useful for biasing these reactions toward just one of two mirror-image products. For the most part, though, these chiral catalysts have interacted with basic sites such as carbonyl groups. Tsuji et al. now extend asymmetric acid catalysis to simple carbon-carbon double bonds. Their custom imidodiphosphate forms a pocket that orients… Expand
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