Activation of nucleotide-binding domain-like receptor containing protein 3 inflammasome in dendritic cells and macrophages by Streptococcus sanguinis.

@article{Saeki2017ActivationON,
  title={Activation of nucleotide-binding domain-like receptor containing protein 3 inflammasome in dendritic cells and macrophages by Streptococcus sanguinis.},
  author={A Saeki and Toshihiko Suzuki and A. Hasebe and Ryousuke Kamezaki and Mari Fujita and Futoshi Nakazawa and Ken-ichiro Shibata},
  journal={Cellular microbiology},
  year={2017},
  volume={19 3}
}
Streptococcus sanguinis is frequently isolated from the blood of patients with infective endocarditis and contributes to the pathology of this disease through induction of interleukin (IL)-1β responsible for the development of the disease. However, the mechanism of IL-1β induction remains unknown. In this study, S. sanguinis activated a murine dendritic cell (DC) to induce IL-1β and this activity was attenuated by silencing the mRNAs of nucleotide-binding domain-like receptor containing protein… CONTINUE READING