Activation of nucleation promoting factors for directional actin filament elongation: allosteric regulation and multimerization on the membrane.

@article{Suetsugu2013ActivationON,
  title={Activation of nucleation promoting factors for directional actin filament elongation: allosteric regulation and multimerization on the membrane.},
  author={Shiro Suetsugu},
  journal={Seminars in cell & developmental biology},
  year={2013},
  volume={24 4},
  pages={267-71}
}
Nucleation promoting factors (NPFs) activate the Arp2/3 complex to produce branched actin filaments. Branched actin filaments are observed in most organelles, and specific NPFs, such as WASP, N-WASP, WAVEs, WASH, and WHAMM, exist for each organelle. Interestingly, Arp2/3 and NPFs are both inactive by themselves, and thus require activation. The exposure of… CONTINUE READING