Activation of nuclear receptors: a perspective from structural genomics.

@article{Li2003ActivationON,
  title={Activation of nuclear receptors: a perspective from structural genomics.},
  author={Yong Li and Millard H. Lambert and Hailou Xu},
  journal={Structure},
  year={2003},
  volume={11 7},
  pages={741-6}
}
Crystal structures of more than two dozen different nuclear receptor ligand binding domains have defined a simple paradigm of receptor activation, in which agonist binding induces the activation function-2 (AF-2) helix to form a charge clamp for coactivator recruitment. Recent structural studies present a surprising contrast. Activation of the mouse LRH-1 receptor is independent of a bound agonist despite its large ligand binding pocket, whereas the activation of the Drosophila DHR38 receptor… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 59 extracted citations

Similar Papers

Loading similar papers…