Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.

@article{Dong2009ActivationON,
  title={Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.},
  author={Bingning Dong and Pradip Kumar Saha and Wendong Huang and Wen-ling Chen and Lutfi Abu-Elheiga and Salih J. Wakil and Robert A. Moffitt Johns Hopkins University David Stevens and Olga Ilkayeva and Christopher B. Newgard and Lawrence K Chan and David D. Moore},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 44},
  pages={18831-6}
}
Constitutive androstane receptor CAR (NR1I3) has been identified as a central mediator of coordinate responses to xenobiotic and endobiotic stress. Here we use leptin-deficient mice (ob/ob) and ob/ob, CAR(-/-) double mutant mice to identify a metabolic role of CAR in type 2 diabetes. Activation of CAR significantly reduces serum glucose levels and improves glucose tolerance and insulin sensitivity. Gene expression analyses and hyperinsulinemic euglycemic clamp results suggest that CAR… CONTINUE READING
80 Citations
39 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 80 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Gene expression profiling of rat liver treated with serum triglyceride-decreasing compounds

  • K Omura
  • J Toxicol Sci 32:387–399
  • 2007

Similar Papers

Loading similar papers…