Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.

  title={Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.},
  author={Bingning Dong and Pradip Kumar Saha and Wendong Huang and Wen-ling Chen and Lutfi Abu-Elheiga and Salih J. Wakil and Robert A. Moffitt Johns Hopkins University David Stevens and Olga Ilkayeva and Christopher B. Newgard and Lawrence K Chan and David D. Moore},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 44},
Constitutive androstane receptor CAR (NR1I3) has been identified as a central mediator of coordinate responses to xenobiotic and endobiotic stress. Here we use leptin-deficient mice (ob/ob) and ob/ob, CAR(-/-) double mutant mice to identify a metabolic role of CAR in type 2 diabetes. Activation of CAR significantly reduces serum glucose levels and improves glucose tolerance and insulin sensitivity. Gene expression analyses and hyperinsulinemic euglycemic clamp results suggest that CAR… CONTINUE READING
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