Activation of nuclear factor-kappaB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide.

@article{Wang2002ActivationON,
  title={Activation of nuclear factor-kappaB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide.},
  author={Suwei Wang and Srigiridhar Kotamraju and Eugene A. Konorev and Shasi V Kalivendi and Jean Maximilien Joseph and Balaraman Kalyanaraman},
  journal={The Biochemical journal},
  year={2002},
  volume={367 Pt 3},
  pages={
          729-40
        }
}
Doxorubicin (DOX) is a widely used anti-tumour drug. Cardiotoxicity is a major toxic side effect of DOX therapy. Although recent studies implicated an apoptotic pathway in DOX-induced cardiotoxicity, the mechanism of DOX-induced apoptosis remains unclear. In the present study, we investigated the role of reactive oxygen species and the nuclear transcription factor nuclear factor kappaB (NF-kappaB) during apoptosis induced by DOX in bovine aortic endothelial cells (BAECs) and adult rat… CONTINUE READING

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Inhibition of doxorubicin - induced cardiomyocyte apoptosis by metalloporphyrins : is it due to ROS scavenging or Hsp induction ?

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