Activation of nuclear factor kappaB by polyamines in breast cancer cells.

@article{Shah1999ActivationON,
  title={Activation of nuclear factor kappaB by polyamines in breast cancer cells.},
  author={Nand K Shah and T J Thomas and Akira Shirahata and Leonard H. Sigal},
  journal={Biochemistry},
  year={1999},
  volume={38 45},
  pages={14763-74}
}
Polyamines-putrescine, spermidine, and spermine-are involved in the growth of breast cancer cells. A possible target of polyamine action is at the site of interaction of transcription factors with their response elements. NF-kappaB is a member of the rel family of transcription factors that regulate transcription of genes in the proliferative/anti-apoptotic pathways. We performed electrophoretic mobility shift assays to study the role of polyamines in NF-kappaB binding to NF-kappaB response… CONTINUE READING

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