Activation of nuclear factor-kappa b transcriptional activity in airway epithelial cells by thioredoxin but not by N-acetyl-cysteine and glutathione.

@article{Harper2001ActivationON,
  title={Activation of nuclear factor-kappa b transcriptional activity in airway epithelial cells by thioredoxin but not by N-acetyl-cysteine and glutathione.},
  author={Richart W Harper and Kaichun Wu and Mary Mann-Jong Chang and Ken Yoneda and Rui Pan and Sekhar P. M. Reddy and Reen Wu},
  journal={American journal of respiratory cell and molecular biology},
  year={2001},
  volume={25 2},
  pages={178-85}
}
Increasing evidence indicates that intracellular redox status modulates the activity of various transcriptional factors, including nuclear factor (NF)-kappa B and activator protein-1. Our laboratory has been interested in characterizing the role thioredoxin (TRX) plays in regulating cellular redox status in airway epithelium. TRX is a small, ubiquitous protein with two redox-active half-cysteine residues, -Cys-Gly-Pro-Cys, in its active center. Using primary passage-1 human tracheobronchial… CONTINUE READING

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