Activation of nonspecific killer cells by interleukin 2-containing supernatants.

  title={Activation of nonspecific killer cells by interleukin 2-containing supernatants.},
  author={Hung Sia Teh and M. Yu},
  journal={Journal of immunology},
  volume={131 4},
  • H. TehM. Yu
  • Published 1 October 1983
  • Biology, Medicine
  • Journal of immunology
In the absence of specific antigen stimulation, nonspecific killer cells were induced by culturing C57BL/6 lymph node or spleen cells with interleukin 2-containing supernatants. These supernatants were obtained from stimulation of either rat spleen cells with concanavalin A or a variant of the T cell lymphoma, EL4 (H-2b) with phorbol myristic acetate. The ability of the EL4 supernatant to induce nonspecific killer cells was abrogated by absorption with an interleukin 2-dependent T cell line or… 

Response of resting human peripheral blood natural killer cells to interleukin 2

The present study shows that recombinant interleukin 2 (IL-2) purified to homogeneity induces a rapid and potent enhancement of spontaneous cytotoxicity of human peripheral blood lymphocytes. The

Lysis of primary hepatic tumours by lymphokine activated killer cells.

It is concluded that the adoptive immunotherapy with combined rIL-2 and lymphokine activated killer may be worth trying in early cases of primary hepatocellular carcinoma.

Neoplastic cells as targets of spontaneously cytotoxic lymphocytes: studies with natural killer-like cell lines

  • A. Lagarde
  • Biology
    Cancer and Metastasis Reviews
  • 2004
Sialylated glycoconjugates exposed on the external face of the tumor cell membrane appear to be essential determinants in the interaction between NK cells and their targets.

Suppression of cytotoxic responses by a supernatant factor derived from Mycoplasma hyorhinis-infected mammalian cell lines

A class of interleukin-2-dependent T-cell clones, isolated from a murine fetal thymus, was previously shown to suppress the induction of cytotoxic responses to alloantigens and the production of suppressor factor in infected cultures was independent of the viability or the protein synthesis capability of the mammalian cells, suggesting that it was produced by M. hyorhinis.

Induction of cytolytic cells by pure recombinant human interleukin 2

Purified recombinant human interleukin 2, produced in Escherichia coli, was sufficient to generate cytolytic cells in concanavalin A‐stimulated, T helper cell‐depleted (Lyt‐1.1−) or accessory

Murine and Human T Cell Factors that Induce the Differentiation of Normal Mouse Lymphocytes into Cytotoxic Cells Copurify with Interleukin 2

The present data may indicate that the T‐LPF and IL‐2 activities studied in the present systems are borne by the same molceule(s) (=IL‐2?), as current hypotheses on the cellular and molecular requirements for the generation of cytotoxic T cells are discussed.

Generation of IL-2 dependent bovine cytotoxic T lymphocyte clones reactive against BHV-1 infected target cells: loss of genetic restriction and virus specificity.

This is the first report of cloned bovine cytotoxic T lymphocytes reactive against BHV-1 and the generation from these clones of promiscuous cytot toxic activity against both virus-infected and non- Infected bovines target cells.

In vivo effects of recombinant human interleukin 2 on antitumor and antiviral natural immunity in induced or natural murine immunodeficiency states.

The rIL-2 therapy effectively enhances both antitumor and antiviral NK/LAK activity and results in a noticeable increase in asialo-GM1-positive cells in the spleens of treated mice as well as a significant increase in IL-2 receptor expression as monitored by either cytometry or radioligand binding.