Activation of nitric oxide signaling through muscarinic receptors in submandibular glands by primary Sjögren syndrome antibodies.

@article{Leirs1999ActivationON,
  title={Activation of nitric oxide signaling through muscarinic receptors in submandibular glands by primary Sj{\"o}gren syndrome antibodies.},
  author={Claudia P{\'e}rez Leir{\'o}s and Leonor Sterin-Borda and Osvaldo Hubscher and Roberto Arana and Enri S. Borda},
  journal={Clinical immunology},
  year={1999},
  volume={90 2},
  pages={190-5}
}
Primary Sjögren Syndrome is a chronic autoimmune disease characterized by exocrine gland dysfunction. Here we present evidence of the activation of nitric oxide signaling cascade by circulating antibodies of patients with Sjögren Syndrome in rat submandibular glands. Constitutive nitric oxide synthase and cyclic GMP levels are modulated by Sjögren IgGs through the activation of muscarinic acetylcholine receptors on the glands. The effects are similar to those produced by the agonist carbachol… CONTINUE READING
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