Activation of natural killer cells via the p75 interleukin 2 receptor

@article{Phillips1989ActivationON,
  title={Activation of natural killer cells via the p75 interleukin 2 receptor},
  author={Joseph H. Phillips and Toshikazu Takeshita and Kazuo Sugamura and Lewis L. Lanier},
  journal={The Journal of Experimental Medicine},
  year={1989},
  volume={170},
  pages={291 - 296}
}
The IL-2R is composed of at least two subunits, the p55 (CD25/Tac) and p75 glycoproteins. The p75 IL-2R is expressed preferentially on resting human peripheral blood NK cells, but is not detected on substantial proportions of T and B lymphocytes, monocytes, or granulocytes. Anti-p75 IL-2R mAb substantially inhibits the early events associated with NK cell activation by IL-2, including inhibition of cytotoxic activity and induction of the CD69 early activation antigen. While anti-p55 IL-2R mAb… CONTINUE READING

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