Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus.

@article{Zeng2003ActivationON,
  title={Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus.},
  author={Defu Zeng and Yinping Liu and St{\'e}phan{\'e} Sidobre and Mitchell Kronenberg and Samuel Strober},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={112 8},
  pages={1211-22}
}
In vivo treatment of mice with the natural killer T (NKT) cell ligand, alpha-galactosylceramide (alphaGalCer), ameliorates autoimmune diabetes and experimental autoimmune encephalomyelitis (EAE) by shifting pathogenic Th1-type immune responses to nonpathogenic Th2-type responses. In the current study, in vivo activation of NKT cells in adult NZB/W mice by… CONTINUE READING