Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice.

@article{Saubermann2000ActivationON,
  title={Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice.},
  author={Lawrence J. Saubermann and Paul David Beck and Ype de Jong and Richard S. Pitman and Marianne Ryan and Hyun Sil Kim and Mark Exley and Scott B. Snapper and Steven P. Balk and S. J. van der Hagen and Osamu Kanauchi and Kazuhiro Motoki and Takahiro Sakai and Cox Terhorst and Yasuhiko Koezuka and Daniel K. Podolsky and Richard S Blumberg},
  journal={Gastroenterology},
  year={2000},
  volume={119 1},
  pages={119-28}
}
BACKGROUND & AIMS CD1d is a major histocompatibility complex class I-like molecule that presents glycolipid antigens to a subset of natural killer (NK)1.1(+) T cells. These NK T cells exhibit important immunoregulatory functions in several autoimmune disease models. METHODS To investigate whether CD1d and NK T cells have a similar role in intestinal inflammation, the effects of the glycolipid, alpha-galactosylceramide (alpha-GalCer), on dextran sodium sulfate (DSS)-induced colitis were… CONTINUE READING

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