Activation of mutagens by hepatocytes and liver 9000 X g supernatant from human origin in the Salmonella typhimurium mutagenicity assay. Comparison with rat liver preparations.

@article{Neis1986ActivationOM,
  title={Activation of mutagens by hepatocytes and liver 9000 X g supernatant from human origin in the Salmonella typhimurium mutagenicity assay. Comparison with rat liver preparations.},
  author={John M. Neis and Sing Hiem Yap and P J van Gemert and Hennie M. J. Roelofs and R. P. Bos and Paul T Henderson},
  journal={Mutation research},
  year={1986},
  volume={164 1},
  pages={41-51}
}
The mutagenicity of 10 known genotoxic compounds, of several chemical classes, was measured in Salmonella typhimurium mutagenicity assays comprising isolated human hepatocytes or human liver 9000 X g supernatant (S9) from 4 different individuals, as activating system. The mutagenic activity of several compounds as determined with the Salmonella/hepatocyte… CONTINUE READING