Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.

@article{Weintraub1989ActivationOM,
  title={Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.},
  author={H M Weintraub and Stephen J. Tapscott and Robert L. Davis and Mathew J Thayer and Mohammed Amin Adam and Andrew B. Lassar and A Dusty Miller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 14},
  pages={5434-8}
}
MyoD is a master regulatory gene for myogenesis. Under the control of a retroviral long terminal repeat, MyoD was expressed in a variety of differentiated cell types by using either a DNA transfection vector or a retrovirus. Expression of muscle-specific proteins was observed in chicken, human, and rat primary fibroblasts and in differentiated melanoma, neuroblastoma, liver, and adipocyte lines. The ability of MyoD to activate muscle genes in a variety of differentiated cell lines suggests that… CONTINUE READING
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