Activation of muscarinic receptors protects against retinal neurons damage and optic nerve degeneration in vitro and in vivo models.

@article{Tan2014ActivationOM,
  title={Activation of muscarinic receptors protects against retinal neurons damage and optic nerve degeneration in vitro and in vivo models.},
  author={Pan-Pan Tan and Hai-Hong Yuan and Xu Zhu and Yong-yao Cui and Hui Li and Xue-mei Feng and Yu Qiu and HongZhuan Chen and Wei Zhou},
  journal={CNS neuroscience & therapeutics},
  year={2014},
  volume={20 3},
  pages={227-36}
}
AIMS Muscarinic acetylcholine receptor agonist pilocarpine reduces intraocular pressure (IOP) of glaucoma mainly by stimulating ciliary muscle contraction and then increasing aqueous outflow. It is of our great interest to know whether pilocarpine has the additional properties of retinal neuroprotection independent of IOP lowering in vitro and in vivo models. METHODS In rat primary retinal cultures, cell viability was measured using an MTT assay and the trypan blue exclusion method… CONTINUE READING
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