Activation of muscarinic receptors inhibits spinal dorsal horn projection neurons: role of GABAB receptors

@article{Chen2004ActivationOM,
  title={Activation of muscarinic receptors inhibits spinal dorsal horn projection neurons: role of GABAB receptors},
  author={Show-An Chen and Hui-Lin Pan},
  journal={Neuroscience},
  year={2004},
  volume={125},
  pages={141-148}
}
Spinally administered muscarinic receptor agonists or acetylcholinesterase inhibitors produce efficacious analgesia. However, the mechanisms of the antinociceptive actions of muscarinic agonists in the spinal cord are not fully known. Previous in vitro studies have shown that muscarinic agonists increase GABA release and reduce the glutamatergic synaptic input to lamina II interneurons through GABAB receptors in the spinal cord. In the present study, we studied the effect of muscarinic agents… Expand
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