Activation of muscarinic receptors increases the concentration of free Na+ in mouse pancreatic B-cells.

@article{Gilon1993ActivationOM,
  title={Activation of muscarinic receptors increases the concentration of free Na+ in mouse pancreatic B-cells.},
  author={Patrick Gilon and Jean-Claude Henquin},
  journal={FEBS letters},
  year={1993},
  volume={315 3},
  pages={353-6}
}
The fluorescent probe SBFI was used to monitor the influence of acetylcholine (ACh) on the cytosolic concentration of free Na+ (Na+i) in single mouse pancreatic B-cells. In the presence of 3 mM glucose and 135 mM extracellular Na+, Na+i averaged 16.6 mM. ACh (100 microM) increased Na+i by approximately 80%. This rise was prevented by atropine, a blocker of muscarinic receptors, and by omission of extracellular Na+, but still occurred if the sodium pump was blocked by ouabain. It was unaffected… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…