Activation of muscarinic acetylcholine receptors enhances the release of endogenous cannabinoids in the hippocampus.

@article{Kim2002ActivationOM,
  title={Activation of muscarinic acetylcholine receptors enhances the release of endogenous cannabinoids in the hippocampus.},
  author={Jimok Kim and Masako Isokawa and Catherine A. Ledent and Bradley E. Alger},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 23},
  pages={10182-91}
}
Endogenous cannabinoids (endocannabinoids) are endogenous compounds that resemble the active ingredient of marijuana and activate the cannabinoid receptor in the brain. They mediate retrograde signaling from principal cells to both inhibitory ["depolarization-induced suppression of inhibition" (DSI)] and excitatory ("depolarization-induced suppression of excitation") afferent fibers. Transient endocannabinoid release is triggered by voltage-dependent Ca(2+) influx and is upregulated by group I… CONTINUE READING
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