Activation of murine invariant NKT cells promotes susceptibility to candidiasis by IL-10 induced modulation of phagocyte antifungal activity.

@article{Haraguchi2016ActivationOM,
  title={Activation of murine invariant NKT cells promotes susceptibility to candidiasis by IL-10 induced modulation of phagocyte antifungal activity.},
  author={Norihiro Haraguchi and Norihiro Kikuchi and Yuko Morishima and Masashi Matsuyama and Hirofumi Sakurai and Akira Shibuya and Kazuko Shibuya and Masaru Taniguchi and Yukio Ishii},
  journal={European journal of immunology},
  year={2016},
  volume={46 7},
  pages={1691-703}
}
Invariant NKT (iNKT) cells play an important role in a variety of antimicrobial immune responses due to their ability to produce high levels of immune-modulating cytokines. Here, we investigated the role of iNKT cells in host defense against candidiasis using Jα18-deficient mice (Jα18(-/-) ), which lack iNKT cells. Jα18(-/-) mice were more resistant to the development of lethal candidiasis than wild-type (WT) mice. In contrast, treatment of WT mice with the iNKT cell activating ligand… CONTINUE READING
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