Activation of murine B lymphocytes. III. Stimulation of B lymphocyte clonal growth with lipopolysaccharide and dextran sulfate.

@article{Wetzel1981ActivationOM,
  title={Activation of murine B lymphocytes. III. Stimulation of B lymphocyte clonal growth with lipopolysaccharide and dextran sulfate.},
  author={G. D. Wetzel and John R. Kettman},
  journal={Journal of immunology},
  year={1981},
  volume={126 2},
  pages={
          723-8
        }
}
Proliferation of single B cells was observed in response to the combination of LPS and DXS when spleen cells were placed into Terasaki plates at dilutions where the majority of wells containing cells contained one cell. Clones derived from a single cell exhibited varying morphologies and growth characteristics. Neither filler cells nor conditioned medium was required for these responses. Since isolated cells were stimulated, we conclude that B cells can be activated to clonal growth in the… CONTINUE READING
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