Activation of multiple growth regulatory genes following inducible expression of IRF-1 or IRF/RelA fusion proteins

@article{Nguyen1997ActivationOM,
  title={Activation of multiple growth regulatory genes following inducible expression of IRF-1 or IRF/RelA fusion proteins},
  author={Hannah N Nguyen and Rongtuan Lin and John Hiscott},
  journal={Oncogene},
  year={1997},
  volume={15},
  pages={1425-1435}
}
Interferon Regulatory Factor (IRF)-1 has been characterized as an important growth regulatory and immunomodulatory transcription factor. To further characterize the potential targets of IRF-1 antiproliferative activity, IRF-1 was expressed under the control of the tetracycline-inducible system in murine NIH3T3 cells. Due to their ability to mimic IRF-1 transactivator function, the regulatory potential of IRF-1/RelA and IRF-2/RelA fusion proteins consisting of the DNA binding domains of IRF-1 or… CONTINUE READING

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