Activation of mouse ribosomal RNA genes at the 2-cell stage

  title={Activation of mouse ribosomal RNA genes at the 2-cell stage},
  author={Wolfgang Engel and Maria Teresa Zenzes and Michael Schmid},
  journal={Human Genetics},
The Ag-AS method, developed by Goodpasture and Bloom (1975) stains transcriptionally active nucleolus organizer regions (NORs) on the chromosomes and in the interphase nuclei. Metaphases and interphase nuclei of early mouse embryos (unfertilized eggs, pronucleus stages, 2-, 4-, 8-cell stages, and morulae) were subjected to silver-staining. First staining of a single chromosome bearing an NOR was observed at the 2-cell stage. At the 4-cell stage 4–6 chromosomes, and at the 8-cell stage… CONTINUE READING
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