Activation of mouse natural killer T cells accelerates liver regeneration after partial hepatectomy.

@article{Nakashima2006ActivationOM,
  title={Activation of mouse natural killer T cells accelerates liver regeneration after partial hepatectomy.},
  author={Hiroyuki Nakashima and Takuo Inui and Yoshiko Habu and Manabu Kinoshita and Shigeaki Nagao and Atsushi Kawaguchi and Soichiro Miura and Nariyoshi Shinomiya and H. Yagita and Shuhji Seki},
  journal={Gastroenterology},
  year={2006},
  volume={131 5},
  pages={1573-83}
}
BACKGROUND & AIMS Activation of natural killer T cells with the synthetic ligand alpha-galactosylceramide (alpha-GalCer) induced hepatotoxicity through the tumor necrosis factor (TNF) and Fas-ligand-mediated pathway in aged mice. The aim of this study was to elucidate how alpha-GalCer-activated natural killer T cells function in hepatocyte proliferation and liver regeneration in partially hepatectomized (PHx) mice. METHODS Mice were injected with alpha-GalCer at 36 hours after 70% PHx… CONTINUE READING

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Natural killer T cells in liver injury, inflammation and cancer.

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