Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths.

@article{Wolf2008ActivationOM,
  title={Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths.},
  author={Cynthia J. Wolf and Margy L Takacs and Judith E. Schmid and Christopher D. Lau and Barbara Abbott},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={106 1},
  pages={162-71}
}
Perfluoroalkyl acids (PFAAs) are surfactants used in consumer products and persist in the environment. Some PFAAs elicit adverse effects on rodent development and survival. PFAAs can activate peroxisome proliferator-activated receptor alpha (PPARalpha) and may act via PPARalpha to produce some of their effects. This study evaluated the ability of numerous PFAAs to induce mouse and human PPARalpha activity in a transiently transfected COS-1 cell assay. COS-1 cells were transfected with either a… CONTINUE READING

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