Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths.

@article{Wolf2008ActivationOM,
  title={Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths.},
  author={C. Wolf and Margy L. Takacs and J. Schmid and Christopher Lau and B. Abbott},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={106 1},
  pages={
          162-71
        }
}
  • C. Wolf, Margy L. Takacs, +2 authors B. Abbott
  • Published 2008
  • Chemistry, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
  • Perfluoroalkyl acids (PFAAs) are surfactants used in consumer products and persist in the environment. Some PFAAs elicit adverse effects on rodent development and survival. PFAAs can activate peroxisome proliferator-activated receptor alpha (PPARalpha) and may act via PPARalpha to produce some of their effects. This study evaluated the ability of numerous PFAAs to induce mouse and human PPARalpha activity in a transiently transfected COS-1 cell assay. COS-1 cells were transfected with either a… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 71 REFERENCES
    Activation of Mouse and Human Peroxisome Proliferator-Activated Receptors ( , / , ) by Perfluorooctanoic Acid and Perfluorooctane Sulfonate
    212
    trans-activation of PPARalpha and induction of PPARalpha target genes by perfluorooctane-based chemicals.
    57
    trans-Activation of PPARα and Induction of PPARα Target Genes by Perfluorooctane-Based Chemicals
    123
    Mechanisms of peroxisome proliferation by perfluorooctanoic acid and endogenous fatty acids.
    57
    Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters.
    168
    trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals.
    162