Activation of mitogen-activated protein kinases via CD40 is distinct from that stimulated by surface IgM on B cells.

@article{Kashiwada1996ActivationOM,
  title={Activation of mitogen-activated protein kinases via CD40 is distinct from that stimulated by surface IgM on B cells.},
  author={Masatoshi Kashiwada and Yayoi Kaneko and H. Yagita and Ko Okumura and Toshitada Takemori},
  journal={European journal of immunology},
  year={1996},
  volume={26 7},
  pages={1451-8}
}
CD40 plays critical roles in B cell proliferation and differentiation in response to T cell-dependent antigenic stimulation. It has been suggested that CD40-mediated biological activities are transduced by a CD40 receptor-associated factor, CRAF1 and probably by protein tyrosine kinase Lyn and its substrates, phospholipase C gamma (PLC gamma) and phosphatidylinositol-3 kinase (PI-3 kinase). Here, we describe the novel finding that a mitogen-activated protein kinase (MAPK) extracellular signal… CONTINUE READING
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