Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.

@article{Jiang2014ActivationOM,
  title={Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.},
  author={Xian Jiang and Hui Jiang and Zhirong Shen and Xiaodong Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 41},
  pages={14782-7}
}
Intrinsic apoptotic stimuli initiate mammalian cells' apoptotic program by first activating the proteins that have only Bcl-2 homology domain 3 (BH3), such as Bcl-2 interacting mediator of cell death (Bim) and truncated BH3 interacting death domain agonist (tBid), which in turn trigger conformational changes in BCL2-associated X (Bax) and BCL2-antagonist/killer (Bak) proteins that enable oligomer formation on the mitochondria, causing cytochrome c and other apoptogenic proteins in the… CONTINUE READING
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Assembly of the mitochondrial apoptosis-induced channel, MAC

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