Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition.

@article{Rasola2010ActivationOM,
  title={Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition.},
  author={Andrea Rasola and Marco Sciacovelli and Federica Chiara and Boris Pantic and William S. A. Brusilow and Paolo Bernardi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 2},
  pages={726-31}
}
We studied human cancer cell models in which we detected constitutive activation of ERK. A fraction of active ERK was found to be located in mitochondria in RWPE-2 cells, obtained by v-Ki-Ras transformation of the epithelial prostate RWPE-1 cell line; in metastatic prostate cancer DU145 cells; and in osteosarcoma SAOS-2 cells. All these tumor cells… CONTINUE READING