Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid.

@article{Fulda1998ActivationOM,
  title={Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid.},
  author={Simone Fulda and Carsten Scaffidi and Santos A Susin and Peter Heinrich Krammer and Guido Kroemer and Marcus E Peter and K-M. Debatin},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 51},
  pages={
          33942-8
        }
}
Different classes of anticancer drugs may trigger apoptosis by acting on different subcellular targets and by activating distinct signaling pathways. Here, we report that betulinic acid (BetA) is a prototype cytotoxic agent that triggers apoptosis by a direct effect on mitochondria. In isolated mitochondria, BetA directly induces loss of transmembrane potential independent of a benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone-inhibitable caspase. This is inhibited by bongkrekic acid, an agent… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 138 CITATIONS, ESTIMATED Infinity% COVERAGE

138 Citations

0510'99'03'08'13'18
Citations per Year
Semantic Scholar estimates that this publication has 138 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.

Betulinic Acid-induced Apoptosis 33948 by gest on A ril 29, 2016 hp://w w w .jb.org/ D

  • C. Scaffidi, J. P. Medema, P. H. Krammer, M. E. Peter
  • J. Immunol. Methods
  • 1997

Similar Papers

Loading similar papers…