Activation of midline thalamic nuclei by antipsychotic drugs

  title={Activation of midline thalamic nuclei by antipsychotic drugs},
  author={Bruce M Cohen and Weihua Wan and Michael P. Froimowitz and David J. Ennulat and Sara Cherkerzian and Hanna Konieczna},
The thalamus has been proposed as a site which may be involved in the production of the syndrome of schizophrenia and the response of schizophrenic symptoms to treatment. These studies test whether, consistent with this hypothesis, the activation of thalamic nuclei is a shared property of neuroleptic antipsychotic drugs. Rats were given single doses of the typical high and low potency neuroleptics haloperidol (1 mg/kg) and chlorpromazine (20 mg/kg), the atypical neuroleptics thiroridazine (20… CONTINUE READING
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Dopamine, schizophrenia, mania and depression: toward a uniÞed hypothesis of cortico-striatopallido-thalamic function

  • NR Swerdlow, GF Koob
  • Behav Brain Sci
  • 1987
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